Obesity & Inflammatory markers
In which, inflammatory markers like IL-6 ( interleukin -6)& hsCRP(high sensitive c-reactive protein) were assayed in obese people. Obesity contributes to a sub-clinical inflammatory state which increases the risk of development of DM, HT, & Atherosclerosis. As inflammation is the key pathologic process of Atherosclerosis, DM & HT, the levels of these markers of inflammation in obese people & normal individuals was compared in Chennai population. Study revealed elevated levels of hsCRP but IL-6 in our population was not related to elevated levels of hsCRP, though hsCRP is directly regulated by Cytokine IL-6. This indicates polymorphism in IL-6 gene which needs further study.
Obesity & Calcium Metabolism
In Obese Individuals, Intracellular Hypercalcaemia through mVDR (membrane vitamin D receptor) predisposes to adiposity. Hence we evaluated levels of Serum Ca, Phosphorus & Magnesium along with regulatory hormones like intact PTH (parathyroid hormone) & 25(OH) Vit-D(25 Hydroxy Vitamin D) in obese individuals & compared them with normal subjects.
Increasing Dietary Calcium levels through hormonal regulation causes intracellular Hypocalcaemia & inhibition of FAS (Fatty Acid Synthase Complex)complex thus causing weight loss. In our population, normal individuals had dietary deficiency of Calcium & hence there was no significant difference in the levels of Ca between obese & normal individuals.
Association of Metabolic Syndrome in Menopausal women
Menopausal women are at risk of obesity & associated complication due to oestrogen deficiency. This study revealed no significant difference between menopausal & reproductive age group women. This was because Metabolic Syndrome was equally prevalent in reproductive age group also. But obesity in reproductive age group predisposed to oestrogen deficiency due to increased PPAR? (peroxisomal proliferator activated receptor ? co-activator) expression which down regulates FSH (Follicle Stimulating Hormone) mediated activation of aromatase activity. Hence the hypothesis that oestrogen deficiency predisposes to obesity & complications was proved in the study.
Thus these studies reveal that weight reduction in general causes a decrease in risk for development of related conditions like DM, HT & IHD and also increasing dietary calcium intake may cause weight loss.
These studies were carried out by I year M.B.B.S., students Tulsiram Sundar.M, V.Venkatachalam, & V.S. Aarthi respectively, along with Assistant Professors, Dr.G.Komala & Dr.M.Vijayalakshmi under the Guidance of HOD Dr.Revathi Jayakumar & Prof Dr.Nagendran